Drug interactions
Eslicarbazepine + Sildenafil
Severity: Moderate
Eslicarbazepine and Sildenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine is a weak to moderate CYP3A4 inducer and may lower sildenafil concentrations. Reduced effectiveness is possible, though the effect is smaller than with strong inducers.
What this interaction means in plain words
Eslicarbazepine and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eslicarbazepine belongs to Central Nervous System; Sildenafil belongs to Genitourinary.
Why it happens
Induction of CYP3A4 increases sildenafil metabolism.
What to do
Monitor for reduced sildenafil response and adjust the dose within labeled limits if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sildenafil
- Amyl nitrite + Sildenafil Contraindicated
- Atazanavir + Sildenafil Contraindicated
- Cobicistat + Sildenafil Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Sildenafil Contraindicated
- Glyceryl trinitrate pr + Sildenafil Contraindicated
- Isosorbide dinitrate + Sildenafil Contraindicated
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Sildenafil?
MediHelp rates the interaction as moderate. Eslicarbazepine and Sildenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Eslicarbazepine is a weak to moderate CYP3A4 inducer and may lower sildenafil concentrations. Reduced effectiveness is possible, though the effect is smaller than with strong inducers.
How serious is the interaction between Eslicarbazepine and Sildenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced sildenafil response and adjust the dose within labeled limits if needed.
What other medicines interact with Sildenafil?
MediHelp also lists interactions of Sildenafil with, for example, Amyl nitrite, Atazanavir, Cobicistat. The full list is on the Sildenafil page.
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