Drug interactions
Eslicarbazepine + Tofacitinib
Severity: Minor
Eslicarbazepine and Tofacitinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Eslicarbazepine has weak CYP3A4 induction and weak CYP2C19 inhibition, which have opposing effects on tofacitinib exposure. The net effect is likely small and unpredictable.
What this interaction means in plain words
Eslicarbazepine and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eslicarbazepine belongs to Central Nervous System; Tofacitinib belongs to Musculoskeletal.
Why it happens
Weak CYP3A4 induction and weak CYP2C19 inhibition by eslicarbazepine act in opposite directions.
What to do
No empirical dose change; monitor therapeutic response and adverse effects of tofacitinib.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tofacitinib
- Baricitinib + Tofacitinib Contraindicated
- Cladribine + Tofacitinib Contraindicated
- Tofacitinib + Upadacitinib Contraindicated
- Abatacept + Tofacitinib Major
- Anti-thymocyte + Tofacitinib Major
- Antithymocyte globulin equine + Tofacitinib Major
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Tofacitinib?
MediHelp rates the interaction as minor. Eslicarbazepine and Tofacitinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Eslicarbazepine has weak CYP3A4 induction and weak CYP2C19 inhibition, which have opposing effects on tofacitinib exposure. The net effect is likely small and unpredictable.
How serious is the interaction between Eslicarbazepine and Tofacitinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change; monitor therapeutic response and adverse effects of tofacitinib.
What other medicines interact with Tofacitinib?
MediHelp also lists interactions of Tofacitinib with, for example, Baricitinib, Cladribine, Upadacitinib. The full list is on the Tofacitinib page.
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