Drug interactions
Eslicarbazepine + Triazolam
Severity: Moderate
Eslicarbazepine and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is highly dependent on CYP3A4 for clearance, and eslicarbazepine can induce this enzyme. Triazolam exposure may fall, reducing its hypnotic effect. Both agents can also cause CNS depression.
What this interaction means in plain words
Eslicarbazepine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Eslicarbazepine induces CYP3A4, increasing triazolam metabolism.
What to do
Monitor for reduced hypnotic efficacy and adjust the triazolam dose if needed. Watch for additive drowsiness and dizziness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eslicarbazepine and Triazolam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eslicarbazepine
- Eslicarbazepine + Mavacamten Contraindicated
- Eslicarbazepine + Rilpivirine Contraindicated
- Artemether / lumefantrine + Eslicarbazepine Major
- Avapritinib + Eslicarbazepine Major
- Bedaquiline + Eslicarbazepine Major
- Benzhydrocodone / acetaminophen + Eslicarbazepine Major
Frequently asked questions
Can I take Eslicarbazepine with Triazolam?
MediHelp rates the interaction as moderate. Eslicarbazepine and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is highly dependent on CYP3A4 for clearance, and eslicarbazepine can induce this enzyme. Triazolam exposure may fall, reducing its hypnotic effect. Both agents can also cause CNS depression.
How serious is the interaction between Eslicarbazepine and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic efficacy and adjust the triazolam dose if needed. Watch for additive drowsiness and dizziness.
What other medicines interact with Eslicarbazepine?
MediHelp also lists interactions of Eslicarbazepine with, for example, Mavacamten, Rilpivirine, Artemether / lumefantrine. The full list is on the Eslicarbazepine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
