Drug interactions
Esmolol + Fenoldopam
Severity: Moderate
Esmolol and Fenoldopam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fenoldopam is a potent vasodilator and esmolol reduces cardiac output and heart rate, so combined use may cause excessive hypotension. Fenoldopam's reflex tachycardia is blunted by the beta-blocker.
What this interaction means in plain words
Esmolol and Fenoldopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects via dopamine-1 receptor vasodilation and beta-blockade.
What to do
Titrate both agents with continuous blood pressure and heart rate monitoring.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Fenoldopam?
MediHelp rates the interaction as moderate. Esmolol and Fenoldopam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fenoldopam is a potent vasodilator and esmolol reduces cardiac output and heart rate, so combined use may cause excessive hypotension. Fenoldopam's reflex tachycardia is blunted by the beta-blocker.
How serious is the interaction between Esmolol and Fenoldopam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate both agents with continuous blood pressure and heart rate monitoring.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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