Drug interactions
Esmolol + Fexinidazole
Severity: Major
Esmolol and Fexinidazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole can prolong the QT interval and cause bradycardia-related arrhythmia risk, and esmolol slows heart rate. Together they raise the risk of significant bradycardia and rhythm disturbances.
What this interaction means in plain words
Esmolol and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic bradycardic effects; fexinidazole's QT-prolonging effect adds proarrhythmic risk.
What to do
Avoid coadministration when possible. If unavoidable, monitor ECG (heart rate and QTc) and electrolytes.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Fexinidazole?
MediHelp rates the interaction as major. Esmolol and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole can prolong the QT interval and cause bradycardia-related arrhythmia risk, and esmolol slows heart rate. Together they raise the risk of significant bradycardia and rhythm disturbances.
How serious is the interaction between Esmolol and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration when possible. If unavoidable, monitor ECG (heart rate and QTc) and electrolytes.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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