Drug interactions
Esmolol + Hydrochlorothiazide-olmesartan
Severity: Moderate
Esmolol and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol and olmesartan both lower blood pressure, so hypotension may be additive, particularly during esmolol infusion. Beta-blockade can also slightly raise potassium by impairing cellular uptake, which adds to the potassium-retaining effect of olmesartan.
What this interaction means in plain words
Esmolol and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive hypotensive effects, and beta-blockade reduces cellular potassium uptake while ARBs reduce renal potassium excretion.
What to do
Monitor blood pressure and heart rate closely during esmolol infusion. Check potassium in patients with renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Esmolol and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol and olmesartan both lower blood pressure, so hypotension may be additive, particularly during esmolol infusion. Beta-blockade can also slightly raise potassium by impairing cellular uptake, which adds to the potassium-retaining effect of olmesartan.
How serious is the interaction between Esmolol and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate closely during esmolol infusion. Check potassium in patients with renal impairment.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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