Drug interactions
Esmolol + Iodixanol
Severity: Moderate
Esmolol and Iodixanol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Patients on beta-blockers may have more severe reactions to iodinated contrast and may respond poorly to epinephrine used to treat anaphylaxis. Glucagon may be needed for refractory reactions.
What this interaction means in plain words
Esmolol and Iodixanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-blockade blunts the compensatory cardiovascular response and the effect of epinephrine during hypersensitivity reactions.
What to do
Ensure resuscitation equipment is ready and consider glucagon for epinephrine-resistant anaphylaxis. Weigh the need for contrast against a history of previous contrast reaction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Iodixanol?
MediHelp rates the interaction as moderate. Esmolol and Iodixanol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Patients on beta-blockers may have more severe reactions to iodinated contrast and may respond poorly to epinephrine used to treat anaphylaxis. Glucagon may be needed for refractory reactions.
How serious is the interaction between Esmolol and Iodixanol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure resuscitation equipment is ready and consider glucagon for epinephrine-resistant anaphylaxis. Weigh the need for contrast against a history of previous contrast reaction.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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