Drug interactions
Esmolol + Isradipine
Severity: Moderate
Esmolol and Isradipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, and the combination can cause additive hypotension. Beta-blockade may also prevent the reflex tachycardia that normally accompanies dihydropyridine vasodilation, though isradipine has little direct effect on AV conduction.
What this interaction means in plain words
Esmolol and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotensive effects from vasodilation by calcium channel blockade and reduced cardiac output from beta-blockade.
What to do
Monitor blood pressure and heart rate and titrate each drug to response. Reduce doses if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Isradipine?
MediHelp rates the interaction as moderate. Esmolol and Isradipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, and the combination can cause additive hypotension. Beta-blockade may also prevent the reflex tachycardia that normally accompanies dihydropyridine vasodilation, though isradipine has little direct effect on AV conduction.
How serious is the interaction between Esmolol and Isradipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate each drug to response. Reduce doses if symptomatic hypotension occurs.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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