Drug interactions
Esmolol + Levosalbutamol
Severity: Moderate
Esmolol and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Esmolol is a beta-1 selective blocker whose selectivity may be lost at higher doses, and it can antagonize the bronchodilating effect of levosalbutamol. This is of most concern in patients with asthma or COPD, where bronchospasm may occur.
What this interaction means in plain words
Esmolol and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Levosalbutamol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-adrenergic receptors, with loss of cardioselectivity at higher esmolol doses.
What to do
Use the lowest effective esmolol dose and monitor respiratory status and heart rate. Avoid esmolol in patients with significant reactive airway disease if possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Levosalbutamol?
MediHelp rates the interaction as moderate. Esmolol and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Esmolol is a beta-1 selective blocker whose selectivity may be lost at higher doses, and it can antagonize the bronchodilating effect of levosalbutamol. This is of most concern in patients with asthma or COPD, where bronchospasm may occur.
How serious is the interaction between Esmolol and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective esmolol dose and monitor respiratory status and heart rate. Avoid esmolol in patients with significant reactive airway disease if possible.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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