Drug interactions
Esmolol + Lily of the valley
Severity: Moderate
Esmolol and Lily of the valley: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lily of the valley contains cardiac glycosides, which slow AV conduction. Combined with esmolol, bradycardia and AV block may be additive.
What this interaction means in plain words
Esmolol and Lily of the valley can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive depression of AV nodal conduction from cardiac glycoside effect and beta-blockade.
What to do
Avoid concurrent use; if exposure occurs, monitor ECG and heart rate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Lily of the valley?
MediHelp rates the interaction as moderate. Esmolol and Lily of the valley can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lily of the valley contains cardiac glycosides, which slow AV conduction. Combined with esmolol, bradycardia and AV block may be additive.
How serious is the interaction between Esmolol and Lily of the valley?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use; if exposure occurs, monitor ECG and heart rate.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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