Drug interactions
Esmolol + Metaproterenol
Severity: Moderate
Esmolol and Metaproterenol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers oppose the bronchodilator action of metaproterenol and can trigger bronchospasm in patients with asthma or COPD. Cardioselectivity of esmolol lowers but does not eliminate this risk.
What this interaction means in plain words
Esmolol and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors.
What to do
Use the lowest effective esmolol dose and monitor respiratory status. Stop esmolol if bronchospasm develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Metaproterenol?
MediHelp rates the interaction as moderate. Esmolol and Metaproterenol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers oppose the bronchodilator action of metaproterenol and can trigger bronchospasm in patients with asthma or COPD. Cardioselectivity of esmolol lowers but does not eliminate this risk.
How serious is the interaction between Esmolol and Metaproterenol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective esmolol dose and monitor respiratory status. Stop esmolol if bronchospasm develops.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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