Drug interactions
Esmolol + Nitroglycerin rectal
Severity: Moderate
Esmolol and Nitroglycerin rectal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitroglycerin lowers blood pressure and beta-blockers blunt the reflex tachycardia, so hypotension may be more pronounced. The combination is often used intentionally in angina but needs monitoring.
What this interaction means in plain words
Esmolol and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypotension from nitrate venodilation and beta-blocker reduction of cardiac output and reflex tachycardia.
What to do
Monitor blood pressure and heart rate, and adjust doses if symptomatic hypotension occurs. Counsel patients on orthostatic symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Nitroglycerin rectal?
MediHelp rates the interaction as moderate. Esmolol and Nitroglycerin rectal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nitroglycerin lowers blood pressure and beta-blockers blunt the reflex tachycardia, so hypotension may be more pronounced. The combination is often used intentionally in angina but needs monitoring.
How serious is the interaction between Esmolol and Nitroglycerin rectal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, and adjust doses if symptomatic hypotension occurs. Counsel patients on orthostatic symptoms.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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