Drug interactions
Esmolol + Rivastigmine
Severity: Moderate
Esmolol and Rivastigmine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rivastigmine increases vagal tone and can slow the heart rate, and esmolol also reduces heart rate and AV conduction. Together they raise the risk of bradycardia, heart block and syncope.
What this interaction means in plain words
Esmolol and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Esmolol belongs to Cardiovascular; Rivastigmine belongs to Central Nervous System.
Why it happens
Additive bradycardic effects from cholinesterase inhibition and beta-adrenergic blockade.
What to do
Monitor heart rate and ECG during esmolol use in patients taking rivastigmine and titrate esmolol cautiously. Reassess therapy if symptomatic bradycardia or conduction block occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Other interactions of Rivastigmine
Frequently asked questions
Can I take Esmolol with Rivastigmine?
MediHelp rates the interaction as moderate. Esmolol and Rivastigmine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rivastigmine increases vagal tone and can slow the heart rate, and esmolol also reduces heart rate and AV conduction. Together they raise the risk of bradycardia, heart block and syncope.
How serious is the interaction between Esmolol and Rivastigmine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and ECG during esmolol use in patients taking rivastigmine and titrate esmolol cautiously. Reassess therapy if symptomatic bradycardia or conduction block occurs.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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