Drug interactions
Esmolol + Sacubitril / valsartan
Severity: Minor
Esmolol and Sacubitril / valsartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers can modestly raise serum potassium and sacubitril/valsartan can also cause hyperkalemia through angiotensin receptor blockade. Combined hypotensive effects may also occur, though this combination is commonly used intentionally in heart failure. Clinically relevant hyperkalemia is uncommon with esmolol given its short-term intravenous use.
What this interaction means in plain words
Esmolol and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive pharmacodynamic effects on potassium handling (reduced aldosterone effect with valsartan, impaired cellular potassium uptake with beta-blockade) and additive blood pressure lowering.
What to do
Monitor blood pressure during esmolol infusion and check serum potassium and renal function if therapy is prolonged or renal impairment is present.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Esmolol
- Acebutolol + Esmolol Major
- Amifostine + Esmolol Major
- Amiodarone + Esmolol Major
- Celiprolol + Esmolol Major
- Diltiazem + Esmolol Major
- Epinephrine racemic + Esmolol Major
Frequently asked questions
Can I take Esmolol with Sacubitril / valsartan?
MediHelp rates the interaction as minor. Esmolol and Sacubitril / valsartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Beta-blockers can modestly raise serum potassium and sacubitril/valsartan can also cause hyperkalemia through angiotensin receptor blockade. Combined hypotensive effects may also occur, though this combination is commonly used intentionally in heart failure. Clinically relevant hyperkalemia is uncommon with esmolol given its short-term intravenous use.
How serious is the interaction between Esmolol and Sacubitril / valsartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure during esmolol infusion and check serum potassium and renal function if therapy is prolonged or renal impairment is present.
What other medicines interact with Esmolol?
MediHelp also lists interactions of Esmolol with, for example, Acebutolol, Amifostine, Amiodarone. The full list is on the Esmolol page.
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