Drug interactions
Estazolam + Hydroxyzine
Severity: Moderate
Estazolam and Hydroxyzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Estazolam is a hypnotic benzodiazepine and hydroxyzine is a sedating antihistamine, so together they increase drowsiness, psychomotor impairment and next-day sedation. Respiratory depression is possible in vulnerable patients.
What this interaction means in plain words
Estazolam and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABA-A potentiation and central H1-receptor blockade.
What to do
Use the lowest effective doses and monitor for excess sedation, especially in older adults. Advise against driving and alcohol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydroxyzine
- Droperidol + Hydroxyzine Contraindicated
- Hydroxyzine + Pimozide Contraindicated
- Hydroxyzine + Thioridazine Contraindicated
- Hydroxyzine + Vandetanib Contraindicated
- Alfentanil + Hydroxyzine Major
- Amiodarone + Hydroxyzine Major
Frequently asked questions
Can I take Estazolam with Hydroxyzine?
MediHelp rates the interaction as moderate. Estazolam and Hydroxyzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Estazolam is a hypnotic benzodiazepine and hydroxyzine is a sedating antihistamine, so together they increase drowsiness, psychomotor impairment and next-day sedation. Respiratory depression is possible in vulnerable patients.
How serious is the interaction between Estazolam and Hydroxyzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for excess sedation, especially in older adults. Advise against driving and alcohol.
What other medicines interact with Hydroxyzine?
MediHelp also lists interactions of Hydroxyzine with, for example, Droperidol, Pimozide, Thioridazine. The full list is on the Hydroxyzine page.
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