Drug interactions
Estazolam + Lurasidone
Severity: Moderate
Estazolam and Lurasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use may increase drowsiness, dizziness and psychomotor impairment. The risk of falls is higher in older patients.
What this interaction means in plain words
Estazolam and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depressant effects (pharmacodynamic).
What to do
Use the lowest effective estazolam dose for the shortest time and monitor for oversedation and falls. Advise against driving or operating machinery until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lurasidone
- Apalutamide + Lurasidone Contraindicated
- Atazanavir + Lurasidone Contraindicated
- Carbamazepine + Lurasidone Contraindicated
- Clarithromycin + Lurasidone Contraindicated
- Cobicistat + Lurasidone Contraindicated
- Conivaptan + Lurasidone Contraindicated
Frequently asked questions
Can I take Estazolam with Lurasidone?
MediHelp rates the interaction as moderate. Estazolam and Lurasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use may increase drowsiness, dizziness and psychomotor impairment. The risk of falls is higher in older patients.
How serious is the interaction between Estazolam and Lurasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective estazolam dose for the shortest time and monitor for oversedation and falls. Advise against driving or operating machinery until tolerance is established.
What other medicines interact with Lurasidone?
MediHelp also lists interactions of Lurasidone with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Lurasidone page.
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