Drug interactions
Estazolam + Midazolam
Severity: Moderate
Estazolam and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are benzodiazepines, so combining them adds to sedation, psychomotor impairment and respiratory depression. The overall risk of oversedation and loss of airway protection is greater than with either drug alone.
What this interaction means in plain words
Estazolam and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive enhancement of GABA-A receptor mediated CNS depression.
What to do
Avoid giving two benzodiazepines together unless clearly needed; if both are used, reduce doses and monitor sedation level and respiratory status, with continuous monitoring during procedural sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Frequently asked questions
Can I take Estazolam with Midazolam?
MediHelp rates the interaction as moderate. Estazolam and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are benzodiazepines, so combining them adds to sedation, psychomotor impairment and respiratory depression. The overall risk of oversedation and loss of airway protection is greater than with either drug alone.
How serious is the interaction between Estazolam and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving two benzodiazepines together unless clearly needed; if both are used, reduce doses and monitor sedation level and respiratory status, with continuous monitoring during procedural sedation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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