Drug interactions
Estradiol vaginal + Itraconazole
Severity: Minor
Estradiol vaginal and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may raise estradiol concentrations through reduced metabolism. Systemic absorption from vaginal products is low, so the clinical effect is probably limited.
What this interaction means in plain words
Estradiol vaginal and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
CYP3A4 inhibition reduces estradiol metabolism.
What to do
Counsel on estrogen adverse effects such as breast tenderness and unusual vaginal bleeding. Report abnormal bleeding for evaluation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Estradiol vaginal with Itraconazole?
MediHelp rates the interaction as minor. Estradiol vaginal and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Itraconazole may raise estradiol concentrations through reduced metabolism. Systemic absorption from vaginal products is low, so the clinical effect is probably limited.
How serious is the interaction between Estradiol vaginal and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel on estrogen adverse effects such as breast tenderness and unusual vaginal bleeding. Report abnormal bleeding for evaluation.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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