Drug interactions
Estradiol vaginal + Voriconazole
Severity: Minor
Estradiol vaginal and Voriconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole inhibits CYP3A4, which contributes to estradiol clearance, and may raise systemic estradiol exposure. With low-dose vaginal products the systemic effect is usually modest, but estrogen-related adverse effects could be more pronounced.
What this interaction means in plain words
Estradiol vaginal and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Voriconazole inhibits CYP3A4-mediated hepatic and intestinal metabolism of estradiol.
What to do
No routine dose change is needed for low-dose vaginal estradiol; watch for estrogenic effects such as breast tenderness or unexpected bleeding during voriconazole therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Estradiol vaginal with Voriconazole?
MediHelp rates the interaction as minor. Estradiol vaginal and Voriconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Voriconazole inhibits CYP3A4, which contributes to estradiol clearance, and may raise systemic estradiol exposure. With low-dose vaginal products the systemic effect is usually modest, but estrogen-related adverse effects could be more pronounced.
How serious is the interaction between Estradiol vaginal and Voriconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed for low-dose vaginal estradiol; watch for estrogenic effects such as breast tenderness or unexpected bleeding during voriconazole therapy.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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