Drug interactions
Estrogens conjugated synthetic + Gemifloxacin
Severity: Minor
Estrogens conjugated synthetic and Gemifloxacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been proposed to lower estrogen levels by changing gut flora, but there is little evidence that fluoroquinolones do this to a meaningful extent. A clinically relevant loss of estrogen effect is unlikely.
What this interaction means in plain words
Estrogens conjugated synthetic and Gemifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction in enterohepatic recirculation of estrogens from altered gut flora; not established for fluoroquinolones.
What to do
No dose adjustment is required. Ask the patient to report breakthrough bleeding or recurrent vasomotor symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Gemifloxacin
- Arsenic trioxide + Gemifloxacin Contraindicated
- Dofetilide + Gemifloxacin Contraindicated
- Gemifloxacin + Ibutilide Contraindicated
- Gemifloxacin + Pimozide Contraindicated
- Gemifloxacin + Thioridazine Contraindicated
- Gemifloxacin + Vandetanib Contraindicated
Frequently asked questions
Can I take Estrogens conjugated synthetic with Gemifloxacin?
MediHelp rates the interaction as minor. Estrogens conjugated synthetic and Gemifloxacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been proposed to lower estrogen levels by changing gut flora, but there is little evidence that fluoroquinolones do this to a meaningful extent. A clinically relevant loss of estrogen effect is unlikely.
How serious is the interaction between Estrogens conjugated synthetic and Gemifloxacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Ask the patient to report breakthrough bleeding or recurrent vasomotor symptoms.
What other medicines interact with Gemifloxacin?
MediHelp also lists interactions of Gemifloxacin with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Gemifloxacin page.
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