Drug interactions
Estrogens conjugated synthetic + Itraconazole
Severity: Moderate
Estrogens conjugated synthetic and Itraconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Itraconazole may increase estrogen exposure, leading to more estrogenic adverse effects such as breast tenderness, nausea, headache and breakthrough bleeding.
What this interaction means in plain words
Estrogens conjugated synthetic and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Strong CYP3A4 inhibition reduces estrogen metabolism.
What to do
Monitor for estrogen-related adverse effects, and reduce the estrogen dose if they emerge. Reassess if itraconazole is given long term.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Frequently asked questions
Can I take Estrogens conjugated synthetic with Itraconazole?
MediHelp rates the interaction as moderate. Estrogens conjugated synthetic and Itraconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Itraconazole may increase estrogen exposure, leading to more estrogenic adverse effects such as breast tenderness, nausea, headache and breakthrough bleeding.
How serious is the interaction between Estrogens conjugated synthetic and Itraconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen-related adverse effects, and reduce the estrogen dose if they emerge. Reassess if itraconazole is given long term.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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