Drug interactions
Estrogens conjugated synthetic + Ribociclib
Severity: Moderate
Estrogens conjugated synthetic and Ribociclib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Synthetic conjugated estrogens are partly CYP3A4-metabolized, so ribociclib may increase estrogen exposure modestly. Estrogens are also generally avoided in hormone-receptor-positive breast cancer, the main indication for ribociclib.
What this interaction means in plain words
Estrogens conjugated synthetic and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Ribociclib inhibits CYP3A4, reducing estrogen metabolism.
What to do
Review whether systemic estrogen is appropriate in a patient receiving ribociclib. If used, monitor for estrogen-related adverse effects and adjust the dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Frequently asked questions
Can I take Estrogens conjugated synthetic with Ribociclib?
MediHelp rates the interaction as moderate. Estrogens conjugated synthetic and Ribociclib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Synthetic conjugated estrogens are partly CYP3A4-metabolized, so ribociclib may increase estrogen exposure modestly. Estrogens are also generally avoided in hormone-receptor-positive breast cancer, the main indication for ribociclib.
How serious is the interaction between Estrogens conjugated synthetic and Ribociclib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Review whether systemic estrogen is appropriate in a patient receiving ribociclib. If used, monitor for estrogen-related adverse effects and adjust the dose.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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