Drug interactions
Estrogens conjugated synthetic + Voriconazole
Severity: Moderate
Estrogens conjugated synthetic and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase exposure to synthetic conjugated estrogens by inhibiting CYP3A4. This could amplify estrogen-related adverse effects such as breast tenderness, fluid retention or breakthrough bleeding.
What this interaction means in plain words
Estrogens conjugated synthetic and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of estrogens, reducing their clearance.
What to do
Monitor for estrogen excess symptoms while on voriconazole and reduce the estrogen dose if they develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Estrogens conjugated synthetic with Voriconazole?
MediHelp rates the interaction as moderate. Estrogens conjugated synthetic and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase exposure to synthetic conjugated estrogens by inhibiting CYP3A4. This could amplify estrogen-related adverse effects such as breast tenderness, fluid retention or breakthrough bleeding.
How serious is the interaction between Estrogens conjugated synthetic and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogen excess symptoms while on voriconazole and reduce the estrogen dose if they develop.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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