Drug interactions
Estrogens esterified + Voriconazole
Severity: Moderate
Estrogens esterified and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may raise circulating estrogen concentrations from esterified estrogens through CYP3A4 inhibition. Increased estrogenic effects such as breast tenderness, nausea or bleeding changes may occur.
What this interaction means in plain words
Estrogens esterified and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of estrogens, reducing their clearance.
What to do
Monitor for signs of estrogen excess during voriconazole therapy and lower the estrogen dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Estrogens esterified with Voriconazole?
MediHelp rates the interaction as moderate. Estrogens esterified and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may raise circulating estrogen concentrations from esterified estrogens through CYP3A4 inhibition. Increased estrogenic effects such as breast tenderness, nausea or bleeding changes may occur.
How serious is the interaction between Estrogens esterified and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of estrogen excess during voriconazole therapy and lower the estrogen dose if needed.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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