Drug interactions
Estropipate + Voriconazole
Severity: Moderate
Estropipate and Voriconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole may increase estropipate-derived estrogen exposure by inhibiting CYP3A4. Estrogen-related adverse effects could become more noticeable.
What this interaction means in plain words
Estropipate and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Voriconazole inhibits CYP3A4-mediated metabolism of estrogens, reducing their clearance.
What to do
Monitor for estrogenic adverse effects during voriconazole therapy and reduce the estropipate dose if they occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Frequently asked questions
Can I take Estropipate with Voriconazole?
MediHelp rates the interaction as moderate. Estropipate and Voriconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voriconazole may increase estropipate-derived estrogen exposure by inhibiting CYP3A4. Estrogen-related adverse effects could become more noticeable.
How serious is the interaction between Estropipate and Voriconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for estrogenic adverse effects during voriconazole therapy and reduce the estropipate dose if they occur.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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