Drug interactions
Eszopiclone + Ivosidenib
Severity: Moderate
Eszopiclone and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib induces CYP3A4 and may lower eszopiclone concentrations, reducing hypnotic efficacy. The consequence is mainly loss of effect rather than toxicity.
What this interaction means in plain words
Eszopiclone and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Ivosidenib belongs to Oncology.
Why it happens
Induction of CYP3A4 by ivosidenib increases eszopiclone metabolism.
What to do
Monitor for loss of hypnotic effect and consider an alternative agent if insomnia is not controlled. Avoid escalating the dose beyond labeled limits.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Eszopiclone with Ivosidenib?
MediHelp rates the interaction as moderate. Eszopiclone and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib induces CYP3A4 and may lower eszopiclone concentrations, reducing hypnotic efficacy. The consequence is mainly loss of effect rather than toxicity.
How serious is the interaction between Eszopiclone and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of hypnotic effect and consider an alternative agent if insomnia is not controlled. Avoid escalating the dose beyond labeled limits.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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