Drug interactions
Eszopiclone + Larotrectinib
Severity: Minor
Eszopiclone and Larotrectinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Larotrectinib is a CYP3A4 substrate and may weakly inhibit it, so eszopiclone exposure could rise slightly. A meaningful clinical effect is unlikely.
What this interaction means in plain words
Eszopiclone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Eszopiclone belongs to Central Nervous System; Larotrectinib belongs to Oncology.
Why it happens
Possible weak inhibition of CYP3A4-mediated eszopiclone metabolism.
What to do
No routine adjustment is needed; monitor for increased sedation and lower the eszopiclone dose if it appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Eszopiclone and Larotrectinib, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Eszopiclone
Other interactions of Larotrectinib
Frequently asked questions
Can I take Eszopiclone with Larotrectinib?
MediHelp rates the interaction as minor. Eszopiclone and Larotrectinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Larotrectinib is a CYP3A4 substrate and may weakly inhibit it, so eszopiclone exposure could rise slightly. A meaningful clinical effect is unlikely.
How serious is the interaction between Eszopiclone and Larotrectinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for increased sedation and lower the eszopiclone dose if it appears.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
