Drug interactions
Eszopiclone + Lorlatinib
Severity: Moderate
Eszopiclone and Lorlatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lorlatinib is a moderate CYP3A4 inducer and may lower eszopiclone concentrations. The hypnotic effect may be weaker, while lorlatinib itself can cause CNS effects such as mood changes and cognitive effects.
What this interaction means in plain words
Eszopiclone and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Lorlatinib belongs to Oncology.
Why it happens
Lorlatinib induces CYP3A4, increasing the metabolic clearance of eszopiclone.
What to do
Monitor for reduced hypnotic efficacy and adjust the eszopiclone dose within labeled limits if needed. Be alert to CNS adverse effects from lorlatinib that could be confused with insomnia treatment effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Lorlatinib
- Amobarbital + Lorlatinib Contraindicated
- Apalutamide + Lorlatinib Contraindicated
- Butabarbital + Lorlatinib Contraindicated
- Carbamazepine + Lorlatinib Contraindicated
- Enzalutamide + Lorlatinib Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
Frequently asked questions
Can I take Eszopiclone with Lorlatinib?
MediHelp rates the interaction as moderate. Eszopiclone and Lorlatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lorlatinib is a moderate CYP3A4 inducer and may lower eszopiclone concentrations. The hypnotic effect may be weaker, while lorlatinib itself can cause CNS effects such as mood changes and cognitive effects.
How serious is the interaction between Eszopiclone and Lorlatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced hypnotic efficacy and adjust the eszopiclone dose within labeled limits if needed. Be alert to CNS adverse effects from lorlatinib that could be confused with insomnia treatment effects.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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