Drug interactions
Eszopiclone + Rifabutin
Severity: Moderate
Eszopiclone and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces CYP3A4 and may reduce eszopiclone exposure, although the effect is weaker than with rifampicin. The hypnotic effect may be diminished.
What this interaction means in plain words
Eszopiclone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Eszopiclone belongs to Central Nervous System; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP3A4, increasing the metabolic clearance of eszopiclone.
What to do
Monitor for loss of hypnotic efficacy and adjust the eszopiclone dose within labeled limits if needed. Consider an alternative hypnotic if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eszopiclone
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Eszopiclone with Rifabutin?
MediHelp rates the interaction as moderate. Eszopiclone and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces CYP3A4 and may reduce eszopiclone exposure, although the effect is weaker than with rifampicin. The hypnotic effect may be diminished.
How serious is the interaction between Eszopiclone and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of hypnotic efficacy and adjust the eszopiclone dose within labeled limits if needed. Consider an alternative hypnotic if the response is inadequate.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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