Drug interactions
Eszopiclone + Zuranolone
Severity: Major
Eszopiclone and Zuranolone: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes CNS depression and impaired driving ability, and eszopiclone adds further sedative and psychomotor effects. Combined use may increase somnolence and confusion.
What this interaction means in plain words
Eszopiclone and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Eszopiclone belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic CNS depression through GABA-A receptor positive modulation by both drugs.
What to do
Avoid the combination if possible; otherwise consider dose reduction of one agent. Monitor for excess sedation and counsel against driving.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Eszopiclone
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Eszopiclone with Zuranolone?
MediHelp rates the interaction as major. Eszopiclone and Zuranolone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Zuranolone causes CNS depression and impaired driving ability, and eszopiclone adds further sedative and psychomotor effects. Combined use may increase somnolence and confusion.
How serious is the interaction between Eszopiclone and Zuranolone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination if possible; otherwise consider dose reduction of one agent. Monitor for excess sedation and counsel against driving.
What other medicines interact with Eszopiclone?
MediHelp also lists interactions of Eszopiclone with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Amobarbital. The full list is on the Eszopiclone page.
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