Drug interactions
Etanercept + Measles mumps and rubella vaccine live
Severity: Contraindicated
Etanercept and Measles mumps and rubella vaccine live: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MMR contains live attenuated viruses that may replicate excessively in patients receiving TNF blockade. This raises the risk of disseminated vaccine-strain infection. The vaccine response may also be impaired.
What this interaction means in plain words
Etanercept and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
TNF inhibition weakens immune control of live attenuated viruses.
What to do
Do not give MMR during etanercept treatment. Vaccinate at least 4 weeks before starting etanercept, or defer until after drug discontinuation and washout.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Golimumab Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
- Etanercept + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Etanercept with Measles mumps and rubella vaccine live?
MediHelp rates the interaction as contraindicated. Etanercept and Measles mumps and rubella vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MMR contains live attenuated viruses that may replicate excessively in patients receiving TNF blockade. This raises the risk of disseminated vaccine-strain infection. The vaccine response may also be impaired.
How serious is the interaction between Etanercept and Measles mumps and rubella vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give MMR during etanercept treatment. Vaccinate at least 4 weeks before starting etanercept, or defer until after drug discontinuation and washout.
What other medicines interact with Etanercept?
MediHelp also lists interactions of Etanercept with, for example, Bcg vaccine live, Golimumab, Measles mumps and rubella vaccine. The full list is on the Etanercept page.
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