Drug interactions
Etanercept + Golimumab
Severity: Contraindicated
Etanercept and Golimumab: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are TNF-alpha inhibitors, so combining them duplicates therapy without added benefit. Studies of TNF blocker combinations showed more serious infections and adverse events.
What this interaction means in plain words
Etanercept and Golimumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Etanercept belongs to Musculoskeletal; Golimumab belongs to Musculoskeletal.
Why it happens
Duplicate TNF-alpha blockade causing additive immunosuppression.
What to do
Do not combine two TNF inhibitors. Use a single agent and switch to another class if response is inadequate.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Golimumab
- Bcg vaccine live + Golimumab Contraindicated
- Golimumab + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Golimumab + Measles mumps and rubella vaccine Contraindicated
- Golimumab + Measles mumps and rubella vaccine live Contraindicated
- Golimumab + Measles mumps rubella and varicella vaccine live Contraindicated
- Golimumab + Measles vaccine Contraindicated
Other interactions of Etanercept
- Bcg vaccine live + Etanercept Contraindicated
- Etanercept + Measles mumps and rubella vaccine Contraindicated
- Etanercept + Measles mumps and rubella vaccine live Contraindicated
- Etanercept + Measles mumps rubella and varicella vaccine live Contraindicated
- Etanercept + Measles vaccine Contraindicated
- Etanercept + Rubella vaccine Contraindicated
Frequently asked questions
Can I take Etanercept with Golimumab?
MediHelp rates the interaction as contraindicated. Etanercept and Golimumab are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents are TNF-alpha inhibitors, so combining them duplicates therapy without added benefit. Studies of TNF blocker combinations showed more serious infections and adverse events.
How serious is the interaction between Etanercept and Golimumab?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not combine two TNF inhibitors. Use a single agent and switch to another class if response is inadequate.
What other medicines interact with Golimumab?
MediHelp also lists interactions of Golimumab with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine. The full list is on the Golimumab page.
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