Drug interactions
Ethacrynic acid + Fenoprofen
Severity: Moderate
Ethacrynic acid and Fenoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can reduce the diuretic and antihypertensive effects of loop diuretics and increase the risk of renal impairment, especially with volume depletion. Ethacrynic acid itself may also cause GI bleeding risk.
What this interaction means in plain words
Ethacrynic acid and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Fenoprofen belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, opposing loop diuretic action.
What to do
Monitor diuretic response, weight, blood pressure, renal function and electrolytes, and increase the diuretic dose if needed or stop the NSAID.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethacrynic acid and Fenoprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Fenoprofen?
MediHelp rates the interaction as moderate. Ethacrynic acid and Fenoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can reduce the diuretic and antihypertensive effects of loop diuretics and increase the risk of renal impairment, especially with volume depletion. Ethacrynic acid itself may also cause GI bleeding risk.
How serious is the interaction between Ethacrynic acid and Fenoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor diuretic response, weight, blood pressure, renal function and electrolytes, and increase the diuretic dose if needed or stop the NSAID.
What other medicines interact with Fenoprofen?
MediHelp also lists interactions of Fenoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Fenoprofen page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
