Drug interactions
Ethacrynic acid + Fentanyl
Severity: Minor
Ethacrynic acid and Fentanyl: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids can promote antidiuretic hormone release and may cause urinary retention, which could reduce the response to a loop diuretic. The effect is variable and usually modest.
What this interaction means in plain words
Ethacrynic acid and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethacrynic acid belongs to Cardiovascular; Fentanyl belongs to Musculoskeletal.
Why it happens
Opioid-induced ADH release and urinary retention may oppose diuresis; the evidence is largely theoretical.
What to do
Monitor fluid balance, weight and urine output after starting fentanyl. Adjust the diuretic dose only if fluid retention occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fentanyl
- Alvimopan + Fentanyl Contraindicated
- Fentanyl + Isocarboxazid Contraindicated
- Fentanyl + Olanzapine / samidorphan Contraindicated
- Fentanyl + Phenelzine Contraindicated
- Fentanyl + Tranylcypromine Contraindicated
- Alfentanil + Fentanyl Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Fentanyl?
MediHelp rates the interaction as minor. Ethacrynic acid and Fentanyl have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids can promote antidiuretic hormone release and may cause urinary retention, which could reduce the response to a loop diuretic. The effect is variable and usually modest.
How serious is the interaction between Ethacrynic acid and Fentanyl?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fluid balance, weight and urine output after starting fentanyl. Adjust the diuretic dose only if fluid retention occurs.
What other medicines interact with Fentanyl?
MediHelp also lists interactions of Fentanyl with, for example, Alvimopan, Isocarboxazid, Olanzapine / samidorphan. The full list is on the Fentanyl page.
Full monographs, dosing and an interaction checker in the MediHelp app
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