Drug interactions
Ethacrynic acid + Hydrochlorothiazide-olmesartan
Severity: Moderate
Ethacrynic acid and Hydrochlorothiazide-olmesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic that, with hydrochlorothiazide, produces strong sequential nephron blockade, with substantial risk of hypokalemia, hyponatremia, hypomagnesemia, and volume depletion. Olmesartan may partly offset potassium loss but raises the risk of hypotension and renal impairment when volume is depleted.
What this interaction means in plain words
Ethacrynic acid and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Hydrochlorothiazide-olmesartan belongs to Cardiovascular.
Why it happens
Additive diuretic and natriuretic effects at different nephron sites with additive potassium loss, while ARB-mediated reduction in aldosterone partly opposes it.
What to do
Monitor electrolytes, renal function, volume status and blood pressure, especially at initiation or dose changes. Adjust diuretic doses or supplement potassium and magnesium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-olmesartan
- Aliskiren + Hydrochlorothiazide-olmesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-olmesartan Contraindicated
- Hydrochlorothiazide-olmesartan + Sparsentan Contraindicated
- Acemetacin + Hydrochlorothiazide-olmesartan Major
- Amifostine + Hydrochlorothiazide-olmesartan Major
- Amiloride + Hydrochlorothiazide-olmesartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Hydrochlorothiazide-olmesartan?
MediHelp rates the interaction as moderate. Ethacrynic acid and Hydrochlorothiazide-olmesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic that, with hydrochlorothiazide, produces strong sequential nephron blockade, with substantial risk of hypokalemia, hyponatremia, hypomagnesemia, and volume depletion. Olmesartan may partly offset potassium loss but raises the risk of hypotension and renal impairment when volume is depleted.
How serious is the interaction between Ethacrynic acid and Hydrochlorothiazide-olmesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor electrolytes, renal function, volume status and blood pressure, especially at initiation or dose changes. Adjust diuretic doses or supplement potassium and magnesium as needed.
What other medicines interact with Hydrochlorothiazide-olmesartan?
MediHelp also lists interactions of Hydrochlorothiazide-olmesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-olmesartan page.
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