Drug interactions
Ethacrynic acid + Hydrocortisone
Severity: Moderate
Ethacrynic acid and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs promote urinary potassium loss, so using them together can cause additive hypokalemia. Low potassium raises the risk of arrhythmias and muscle weakness, particularly in patients with heart disease or those taking digoxin.
What this interaction means in plain words
Ethacrynic acid and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Hydrocortisone belongs to Endocrine.
Why it happens
Additive renal potassium wasting from loop diuretic action and mineralocorticoid effect of hydrocortisone.
What to do
Monitor serum potassium and magnesium regularly and replace potassium as needed. Use the lowest effective corticosteroid dose and duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethacrynic acid and Hydrocortisone, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Hydrocortisone?
MediHelp rates the interaction as moderate. Ethacrynic acid and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs promote urinary potassium loss, so using them together can cause additive hypokalemia. Low potassium raises the risk of arrhythmias and muscle weakness, particularly in patients with heart disease or those taking digoxin.
How serious is the interaction between Ethacrynic acid and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium regularly and replace potassium as needed. Use the lowest effective corticosteroid dose and duration.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
