Drug interactions
Ethacrynic acid + Ketorolac
Severity: Moderate
Ethacrynic acid and Ketorolac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketorolac can reduce the diuretic and antihypertensive effects of loop diuretics such as ethacrynic acid and increases the risk of acute kidney injury, particularly in volume-depleted patients. Ketorolac labeling notes reduced diuretic response and renal risk.
What this interaction means in plain words
Ethacrynic acid and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Ketorolac belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandins reduces renal blood flow and sodium excretion, opposing loop diuretic action.
What to do
Monitor urine output, weight, blood pressure and renal function, and correct volume depletion before using ketorolac. Keep the course brief.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketorolac
- Aceclofenac + Ketorolac Contraindicated
- Acemetacin + Ketorolac Contraindicated
- Acetylsalicylic acid + Ketorolac Contraindicated
- Apixaban + Ketorolac Contraindicated
- Argatroban + Ketorolac Contraindicated
- Aspirin / citric acid / sodium bicarbonate + Ketorolac Contraindicated
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Ketorolac?
MediHelp rates the interaction as moderate. Ethacrynic acid and Ketorolac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ketorolac can reduce the diuretic and antihypertensive effects of loop diuretics such as ethacrynic acid and increases the risk of acute kidney injury, particularly in volume-depleted patients. Ketorolac labeling notes reduced diuretic response and renal risk.
How serious is the interaction between Ethacrynic acid and Ketorolac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor urine output, weight, blood pressure and renal function, and correct volume depletion before using ketorolac. Keep the course brief.
What other medicines interact with Ketorolac?
MediHelp also lists interactions of Ketorolac with, for example, Aceclofenac, Acemetacin, Acetylsalicylic acid. The full list is on the Ketorolac page.
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