Drug interactions
Ethacrynic acid + Levosalbutamol
Severity: Moderate
Ethacrynic acid and Levosalbutamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower serum potassium, levosalbutamol through cellular uptake and ethacrynic acid through increased renal potassium excretion. Combined use can cause hypokalemia and increase the risk of arrhythmias, especially with high bronchodilator doses.
What this interaction means in plain words
Ethacrynic acid and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Levosalbutamol belongs to Respiratory.
Why it happens
Additive hypokalemia from beta-2 mediated potassium shift into cells and loop diuretic induced renal potassium loss.
What to do
Monitor serum potassium and magnesium during combined use, especially in acute exacerbations or heart disease. Replace potassium as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Levosalbutamol
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Levosalbutamol?
MediHelp rates the interaction as moderate. Ethacrynic acid and Levosalbutamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower serum potassium, levosalbutamol through cellular uptake and ethacrynic acid through increased renal potassium excretion. Combined use can cause hypokalemia and increase the risk of arrhythmias, especially with high bronchodilator doses.
How serious is the interaction between Ethacrynic acid and Levosalbutamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium during combined use, especially in acute exacerbations or heart disease. Replace potassium as needed.
What other medicines interact with Levosalbutamol?
MediHelp also lists interactions of Levosalbutamol with, for example, Amisulpride, Carvedilol, Fexinidazole. The full list is on the Levosalbutamol page.
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