Drug interactions
Ethacrynic acid + Metformin
Severity: Moderate
Ethacrynic acid and Metformin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loop diuretics can raise blood glucose and impair glucose tolerance in some patients, potentially lessening metformin's effect. Diuretic-induced volume depletion and renal impairment can also increase metformin-associated risk.
What this interaction means in plain words
Ethacrynic acid and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Metformin belongs to Endocrine.
Why it happens
Diuretic-related impairment of glucose tolerance opposes metformin; volume depletion may reduce metformin clearance.
What to do
Monitor blood glucose and renal function, and hold metformin if dehydration or acute kidney injury develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metformin
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Metformin?
MediHelp rates the interaction as moderate. Ethacrynic acid and Metformin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loop diuretics can raise blood glucose and impair glucose tolerance in some patients, potentially lessening metformin's effect. Diuretic-induced volume depletion and renal impairment can also increase metformin-associated risk.
How serious is the interaction between Ethacrynic acid and Metformin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function, and hold metformin if dehydration or acute kidney injury develops.
What other medicines interact with Metformin?
MediHelp also lists interactions of Metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin page.
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