Drug interactions
Ethacrynic acid + Perindopril
Severity: Moderate
Ethacrynic acid and Perindopril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic, and combining it with an ACE inhibitor can cause marked hypotension, particularly at initiation in volume-depleted patients. Acute renal insufficiency may also occur.
What this interaction means in plain words
Ethacrynic acid and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Perindopril belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion makes glomerular filtration angiotensin II dependent, and ACE inhibition removes this support.
What to do
Consider reducing or temporarily holding the diuretic before starting perindopril, and begin with a low dose. Monitor blood pressure, creatinine and potassium during the first weeks.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Perindopril?
MediHelp rates the interaction as moderate. Ethacrynic acid and Perindopril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic, and combining it with an ACE inhibitor can cause marked hypotension, particularly at initiation in volume-depleted patients. Acute renal insufficiency may also occur.
How serious is the interaction between Ethacrynic acid and Perindopril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider reducing or temporarily holding the diuretic before starting perindopril, and begin with a low dose. Monitor blood pressure, creatinine and potassium during the first weeks.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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