Drug interactions
Ethacrynic acid + Telmisartan-amlodipine
Severity: Moderate
Ethacrynic acid and Telmisartan-amlodipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic that adds to the blood pressure lowering of telmisartan-amlodipine and can cause volume depletion. Combined use raises the risk of hypotension and acute kidney injury, and potassium changes can go either way.
What this interaction means in plain words
Ethacrynic acid and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Telmisartan-amlodipine belongs to Cardiovascular.
Why it happens
Additive hypotensive effects, with loop diuretic volume depletion reducing renal perfusion in the presence of ARB-blunted efferent arteriolar tone, and opposing effects on potassium.
What to do
Monitor blood pressure, renal function and serum electrolytes after initiation and dose changes. Consider reducing the diuretic dose in volume-depleted patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethacrynic acid and Telmisartan-amlodipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Telmisartan-amlodipine
- Aliskiren + Telmisartan-amlodipine Contraindicated
- Sparsentan + Telmisartan-amlodipine Contraindicated
- Amifostine + Telmisartan-amlodipine Major
- Amiloride + Telmisartan-amlodipine Major
- Benazepril + Telmisartan-amlodipine Major
- Candesartan + Telmisartan-amlodipine Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Telmisartan-amlodipine?
MediHelp rates the interaction as moderate. Ethacrynic acid and Telmisartan-amlodipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic that adds to the blood pressure lowering of telmisartan-amlodipine and can cause volume depletion. Combined use raises the risk of hypotension and acute kidney injury, and potassium changes can go either way.
How serious is the interaction between Ethacrynic acid and Telmisartan-amlodipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and serum electrolytes after initiation and dose changes. Consider reducing the diuretic dose in volume-depleted patients.
What other medicines interact with Telmisartan-amlodipine?
MediHelp also lists interactions of Telmisartan-amlodipine with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan-amlodipine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
