Drug interactions
Ethacrynic acid + Telmisartan
Severity: Moderate
Ethacrynic acid and Telmisartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethacrynic acid is a potent loop diuretic and can cause marked volume depletion, which increases the blood pressure and renal effects of telmisartan. Potassium loss from the diuretic may be offset by the ARB.
What this interaction means in plain words
Ethacrynic acid and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Telmisartan belongs to Cardiovascular.
Why it happens
Diuretic-induced volume depletion activates the renin-angiotensin system, so ARB blockade produces additive hypotension and reduced glomerular filtration.
What to do
Monitor blood pressure, renal function and electrolytes after starting or changing doses. Reduce the diuretic dose if the patient becomes volume depleted or hypotensive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telmisartan
- Aliskiren + Telmisartan Contraindicated
- Sparsentan + Telmisartan Contraindicated
- Amifostine + Telmisartan Major
- Amiloride + Telmisartan Major
- Amlodipine-benazepril + Telmisartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Telmisartan Major
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Telmisartan?
MediHelp rates the interaction as moderate. Ethacrynic acid and Telmisartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ethacrynic acid is a potent loop diuretic and can cause marked volume depletion, which increases the blood pressure and renal effects of telmisartan. Potassium loss from the diuretic may be offset by the ARB.
How serious is the interaction between Ethacrynic acid and Telmisartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes after starting or changing doses. Reduce the diuretic dose if the patient becomes volume depleted or hypotensive.
What other medicines interact with Telmisartan?
MediHelp also lists interactions of Telmisartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Telmisartan page.
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