Drug interactions
Ethacrynic acid + Terbutaline
Severity: Moderate
Ethacrynic acid and Terbutaline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can lower serum potassium, so combining them may lead to significant hypokalemia. This increases the risk of arrhythmias and muscle weakness, especially in patients with heart disease or on digoxin.
What this interaction means in plain words
Ethacrynic acid and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Terbutaline belongs to Respiratory.
Why it happens
Additive hypokalemia: loop diuretic renal potassium wasting plus beta-2 mediated intracellular potassium shift.
What to do
Monitor serum potassium and magnesium and supplement as needed. Be particularly careful with high-dose or systemic terbutaline.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbutaline
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Terbutaline?
MediHelp rates the interaction as moderate. Ethacrynic acid and Terbutaline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can lower serum potassium, so combining them may lead to significant hypokalemia. This increases the risk of arrhythmias and muscle weakness, especially in patients with heart disease or on digoxin.
How serious is the interaction between Ethacrynic acid and Terbutaline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and supplement as needed. Be particularly careful with high-dose or systemic terbutaline.
What other medicines interact with Terbutaline?
MediHelp also lists interactions of Terbutaline with, for example, Carvedilol, Droperidol, Fexinidazole. The full list is on the Terbutaline page.
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