Drug interactions
Ethacrynic acid + Venlafaxine
Severity: Moderate
Ethacrynic acid and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both venlafaxine (through SIADH) and loop diuretics such as ethacrynic acid (through sodium loss) can lower serum sodium. Together they may increase the risk of hyponatremia, especially in older adults.
What this interaction means in plain words
Ethacrynic acid and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethacrynic acid belongs to Cardiovascular; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive hyponatremia from venlafaxine-associated SIADH and diuretic-induced renal sodium loss.
What to do
Check serum sodium at baseline and after starting or changing doses, particularly in elderly patients. Reassess therapy if sodium falls or symptoms such as confusion or nausea appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Ethacrynic acid
Frequently asked questions
Can I take Ethacrynic acid with Venlafaxine?
MediHelp rates the interaction as moderate. Ethacrynic acid and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both venlafaxine (through SIADH) and loop diuretics such as ethacrynic acid (through sodium loss) can lower serum sodium. Together they may increase the risk of hyponatremia, especially in older adults.
How serious is the interaction between Ethacrynic acid and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum sodium at baseline and after starting or changing doses, particularly in elderly patients. Reassess therapy if sodium falls or symptoms such as confusion or nausea appear.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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