Drug interactions
Ether + Labetalol
Severity: Moderate
Ether and Labetalol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers and inhaled anesthetics such as ether both depress myocardial contractility and can blunt compensatory responses. Together they may cause hypotension, bradycardia and reduced cardiac output during anesthesia.
What this interaction means in plain words
Ether and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative inotropic and hypotensive effects from beta-adrenergic blockade and anesthetic myocardial depression.
What to do
Inform the anesthesiologist of labetalol use and monitor blood pressure and heart rate closely. Consider reducing the labetalol dose or adjusting the anesthetic depth if hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Labetalol
- Amifostine + Labetalol Major
- Amiodarone + Labetalol Major
- Atenolol-chlorthalidone + Labetalol Major
- Atenolol + Labetalol Major
- Betaxolol + Labetalol Major
- Bisoprolol + Labetalol Major
Frequently asked questions
Can I take Ether with Labetalol?
MediHelp rates the interaction as moderate. Ether and Labetalol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers and inhaled anesthetics such as ether both depress myocardial contractility and can blunt compensatory responses. Together they may cause hypotension, bradycardia and reduced cardiac output during anesthesia.
How serious is the interaction between Ether and Labetalol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Inform the anesthesiologist of labetalol use and monitor blood pressure and heart rate closely. Consider reducing the labetalol dose or adjusting the anesthetic depth if hypotension or bradycardia occurs.
What other medicines interact with Labetalol?
MediHelp also lists interactions of Labetalol with, for example, Amifostine, Amiodarone, Atenolol-chlorthalidone. The full list is on the Labetalol page.
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