Drug interactions
Ethinyl estradiol-drospirenone + Exenatide injectable
Severity: Moderate
Ethinyl estradiol-drospirenone and Exenatide injectable: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Exenatide slows gastric emptying, which can delay or reduce absorption of oral drugs such as contraceptives. Estrogen-containing contraceptives may also modestly impair glucose tolerance, partly opposing the glucose-lowering effect of exenatide.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Exenatide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Delayed gastric emptying from exenatide alters oral absorption, and estrogen-induced insulin resistance antagonizes glycemic control.
What to do
Take the contraceptive at least one hour before exenatide and monitor glycemic control, adjusting antidiabetic therapy as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Exenatide injectable?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Exenatide injectable can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Exenatide slows gastric emptying, which can delay or reduce absorption of oral drugs such as contraceptives. Estrogen-containing contraceptives may also modestly impair glucose tolerance, partly opposing the glucose-lowering effect of exenatide.
How serious is the interaction between Ethinyl estradiol-drospirenone and Exenatide injectable?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Take the contraceptive at least one hour before exenatide and monitor glycemic control, adjusting antidiabetic therapy as required.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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