Drug interactions
Ethinyl estradiol-drospirenone + Fenbufen
Severity: Moderate
Ethinyl estradiol-drospirenone and Fenbufen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone can raise serum potassium, and NSAIDs such as fenbufen can add to this by reducing renal potassium excretion. The risk is greater in renal impairment or with other potassium-raising drugs.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hyperkalemia from aldosterone antagonism and NSAID-mediated suppression of renin and renal prostaglandins.
What to do
Check serum potassium during the first cycle if NSAID use is long term or renal function is impaired; prefer short courses at the lowest effective dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Fenbufen?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Fenbufen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone can raise serum potassium, and NSAIDs such as fenbufen can add to this by reducing renal potassium excretion. The risk is greater in renal impairment or with other potassium-raising drugs.
How serious is the interaction between Ethinyl estradiol-drospirenone and Fenbufen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle if NSAID use is long term or renal function is impaired; prefer short courses at the lowest effective dose.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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