Drug interactions
Ethinyl estradiol-drospirenone + Fenoprofen
Severity: Minor
Ethinyl estradiol-drospirenone and Fenoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can suppress renal prostaglandins and the renin-aldosterone axis, reducing potassium excretion. With drospirenone this may add to potassium elevation, which matters mainly with chronic NSAID use or renal impairment.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Fenoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Ethinyl estradiol-drospirenone belongs to Endocrine; Fenoprofen belongs to Musculoskeletal.
Why it happens
Additive potassium retention from aldosterone antagonism (drospirenone) and NSAID-induced suppression of the renin-aldosterone axis and renal prostaglandins.
What to do
For long-term daily NSAID use, check serum potassium during the first cycle. Use the lowest effective NSAID dose, and take extra care in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Fenoprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Fenoprofen
- Fenoprofen + Ketorolac Contraindicated
- Fenoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Fenoprofen Major
- Acemetacin + Fenoprofen Major
- Acetylsalicylic acid + Fenoprofen Major
- Alteplase + Fenoprofen Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Fenoprofen?
MediHelp rates the interaction as minor. Ethinyl estradiol-drospirenone and Fenoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can suppress renal prostaglandins and the renin-aldosterone axis, reducing potassium excretion. With drospirenone this may add to potassium elevation, which matters mainly with chronic NSAID use or renal impairment.
How serious is the interaction between Ethinyl estradiol-drospirenone and Fenoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For long-term daily NSAID use, check serum potassium during the first cycle. Use the lowest effective NSAID dose, and take extra care in patients with renal impairment.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
