Drug interactions
Ethinyl estradiol-drospirenone + Insulin aspart
Severity: Moderate
Ethinyl estradiol-drospirenone and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined hormonal contraceptives can slightly impair glucose tolerance and insulin sensitivity, which may raise insulin requirements in diabetic patients. With modern low-dose formulations the effect is usually small.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ethinyl estradiol-drospirenone belongs to Endocrine; Insulin aspart belongs to Endocrine.
Why it happens
Estrogen and progestin effects reduce peripheral insulin sensitivity, opposing insulin's glucose-lowering action.
What to do
Monitor blood glucose when starting or stopping the contraceptive and adjust insulin dose as needed. Diabetic patients with vascular complications should generally avoid estrogen-containing contraceptives.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Insulin aspart
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Insulin aspart?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined hormonal contraceptives can slightly impair glucose tolerance and insulin sensitivity, which may raise insulin requirements in diabetic patients. With modern low-dose formulations the effect is usually small.
How serious is the interaction between Ethinyl estradiol-drospirenone and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the contraceptive and adjust insulin dose as needed. Diabetic patients with vascular complications should generally avoid estrogen-containing contraceptives.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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