Drug interactions
Ethinyl estradiol-drospirenone + Ketorolac intranasal
Severity: Moderate
Ethinyl estradiol-drospirenone and Ketorolac intranasal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs such as ketorolac can reduce renal potassium excretion. Together they may add to the risk of hyperkalemia, mainly in patients with renal impairment or other potassium-raising drugs. Intranasal dosing gives lower exposure than oral or injected ketorolac, but systemic absorption still occurs.
What this interaction means in plain words
Ethinyl estradiol-drospirenone and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hyperkalemia from drospirenone's aldosterone antagonism and NSAID-induced suppression of renin-aldosterone and renal prostaglandin effects.
What to do
Check serum potassium during the first cycle when the two are used together in patients with renal impairment or on other potassium-raising drugs. Limit the duration of ketorolac therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Ethinyl estradiol-drospirenone and Ketorolac intranasal, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Frequently asked questions
Can I take Ethinyl estradiol-drospirenone with Ketorolac intranasal?
MediHelp rates the interaction as moderate. Ethinyl estradiol-drospirenone and Ketorolac intranasal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Drospirenone has antimineralocorticoid activity and can raise serum potassium, and NSAIDs such as ketorolac can reduce renal potassium excretion. Together they may add to the risk of hyperkalemia, mainly in patients with renal impairment or other potassium-raising drugs. Intranasal dosing gives lower exposure than oral or injected ketorolac, but systemic absorption still occurs.
How serious is the interaction between Ethinyl estradiol-drospirenone and Ketorolac intranasal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium during the first cycle when the two are used together in patients with renal impairment or on other potassium-raising drugs. Limit the duration of ketorolac therapy.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
